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现货,pf-04217903,selleck,美国进口, c-met 抑制剂 ,cas号: 956905-27-4 ,目录号 s1094

现货,pf-博天堂备用

价格: ¥2079

品牌:selelck

货号:s1094

产品详情

文献和实验

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cas号:
956905-27-4
库存:
大量
英文名:
pf-04217903
保存条件:
零下20摄氏度低温保存
供应商:
selelck中国广州办事处
保质期:
两年
规格:
15 ml/5mg
s1094 pf-04217903
信号转导通路: >> >> >>

技术数据:

分子量(mw): 372.38
化学式:

c19h16n8o

溶解度: dmso ≥75mg/ml water <1mg/ml ethanol <1mg/ml
纯度: >99%
稳定性: at -20℃ 2 years
cas号: 956905-27-4

生物活性

pf-04217903 is an orally bioavailabe, small-molecule met tyrosine kinase inhibitor with potential antineoplastic activity. [1]
pf-04217903 demonstrates exquisite kinase selectivity. inhibition studies of the c-met mutants show that pf-04217903 is more susceptible to oncogenic mutations that attenuate potency than pf-02341066. [1]
pf-04217903 was evaluated against multiple kinase selectivity screening panels: invitrogen inc. (125 kinases), millipore/upstate ltd. (105 kinases), university ofdundee (51 kinases), and pfizer in-house (48 kinases) (supporting information). on the basis of the percent inhibition or ic50 values generated from each of these screens, pf-04217903 was estimated to be>1000-fold selective for c-met compared with each of the other kinases included in these collective screening assays. [1]

参考文献

  • enzymatic characterization of c-met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors sergei l. timofeevski, michele a. mctigue, et al. biochemistry 2009;48:5339–5349

客户反馈数据

western blot analysis of c-met, mapk and akt. 0-100nm pf04217903 was added.

如果需要长期保存,请于零下二十度低温保存。
禁止用于人体及治疗!

特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20 ° c ,抗体及蛋白等产品建议-60℃。抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

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