现货,pf-博天堂备用
价格: ¥2079
品牌:selelck
货号:s1094
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文献和实验
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技术数据:
分子量(mw): | 372.38 | |
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化学式: | c19h16n8o |
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溶解度: | dmso ≥75mg/ml water <1mg/ml ethanol <1mg/ml | |
纯度: | >99% | |
稳定性: | at -20℃ 2 years | |
cas号: | 956905-27-4 |
生物活性
pf-04217903 is an orally bioavailabe, small-molecule met tyrosine kinase inhibitor with potential antineoplastic activity. [1]
pf-04217903 demonstrates exquisite kinase selectivity. inhibition studies of the c-met mutants show that pf-04217903 is more susceptible to oncogenic mutations that attenuate potency than pf-02341066. [1]
pf-04217903 was evaluated against multiple kinase selectivity screening panels: invitrogen inc. (125 kinases), millipore/upstate ltd. (105 kinases), university ofdundee (51 kinases), and pfizer in-house (48 kinases) (supporting information). on the basis of the percent inhibition or ic50 values generated from each of these screens, pf-04217903 was estimated to be>1000-fold selective for c-met compared with each of the other kinases included in these collective screening assays. [1]
参考文献
- enzymatic characterization of c-met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors sergei l. timofeevski, michele a. mctigue, et al. biochemistry 2009;48:5339–5349
客户反馈数据
western blot analysis of c-met, mapk and akt. 0-100nm pf04217903 was added. |
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